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KMID : 0370019990130000047
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Chung-Ang Journal of Pharmacal Sciences
1999 Volume.13 No. 0 p.47 ~ p.51
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Transcriptional activation effect in TetR-VP16-mediated transcription activation system by the heterodimer of TetR-VP16 AND TetR
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Abstract
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In TetR-VP16-mediated transcription activation stystem TetR-VP16 hobodimer activates the tet operator modified minimal promoter. To determine the effect of the heterodimer of TetR-VP16 on transcriptional activation from that minimal promoter cotransfection assays were performed with U373 cells. In coexpression of TetR-VP16 and TetR the expression from the minimal promoter was activated 4-12 fold higher than in expression of TetR-VP16, suggesting that the usage of the heterodimer of TetR-VP16 can improve the effecacy of TetR-VP16-mediated transcription activation system
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